Dr. Tyler's clinical practice focuses on GI cancers, melanoma, and sarcoma. He has pioneered neoadjuvant approaches using chemotherapy and/or radiation to tumors of the stomach and pancreas as well as the application of minimally invasive surgery to tumors of the GI tract. He is an expert in the management of regionally advanced and in-transit melanoma and oversees novel clinical trials to manage this form of disease. Dr. Tyler also has extensive experience managing retroperitoneal and abdominal wall sarcomas.

Dr. Tyler serves as chairman of the UTMB Health Department of Surgery and is the holder of the John Woods Harris Distinguished Chairman, Department of Surgery.