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Dr. Self joined UTMB in the Department of Psychiatry and Behavioral Sciences as Assistant Professor in 2018. She works in the Adult Psychiatry Clinic and is also the Co-Director for the Neuroscience and Human Behavior course in the UTMB School of Medicine. Dr. Self received her medical degree from UTMB in 2011. She was one of five students nominated for the Gold Headed Cane Award, the highest honor bestowed upon a graduating medical student at UTMB. She completed her psychiatry residency at Mount Sinai Beth Israel in New York City, graduating in 2015. She was elected to serve as Chief Resident during her final year and received the Arnold Winston Award for Most Outstanding Resident.

Following residency, Dr. Self served as Physician-In-Charge of the Assertive Community Treatment Program at Mount Sinai Beth Israel, which is an outreach program for patients with severe mental illness in the Lower East Side in Manhattan. Additionally she worked as an Attending Psychiatrist in the Comprehensive Psychiatry Emergency Program. While there, she also served as Associate Residency Program Director and Assistant Professor at the Icahn School of Medicine at Mount Sinai. She received the Outstanding Faculty Mentor Award by the New York County Psychiatry Society in 2017.

Currently, she maintains an active faculty practice, enjoys speaking at medical student organization events about the practice of psychiatry, and regularly volunteers at St. Vincent's Student-Run Clinic as faculty.