Dr. Calhoun studies mechanisms of asthma, with a special emphasis on steroid resistance and severe asthma. A focus of his research is dysfunction of the glucocorticoid receptor [GR] in asthma, from both pre- and post-translational mechanisms. In addition, he has interest in cytokine networking, and the regulation of inflammation and its consequences by anti-inflammatory cytokines such as IL-10. Using a murine model, Dr's Calhoun and Ameredes have demonstrated important interactions among inflammation, cytokine regulation, and gaseous signaling molecules. In addition, Dr Calhoun heads the UTMB site for the NIH-funded Asthma Clinical Research Network, a collaborative network of 8 funded centers nationwide that focuses on the key questions of asthma management.
Pennsylvania State University, College of Medicine - State College, PA, MD, 1979
Internal Medicine, Pennsylvania State University, Milton S. Hershey Medical Center - Hershey, PA, 1980
Internal Medicine, Pennsylvania State University, Milton S. Hershey Medical Center - Hershey, PA, 1982
Pulmonary Disease, University of Vermont - Burlington, VT, 1985
Allergy and Immunology, University of Wisconsin - Madison, WI, 1992
American Board of Internal Medicine, Internal Medicine
American Board of Internal Medicine, Pulmonary Disease